Gene regulatory network growth by duplication
نویسندگان
چکیده
منابع مشابه
Regulatory network rewiring by gene duplication
Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from the three referees who agreed to evaluate your manuscript. As you will see from the reports below, the reviewers acknowledged that this work presents a potentially interesting and extensive analysis of phosphorylation network evolution in yeast. The reviewers, however, did raise a series of substa...
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Epistasis has long been recognized as fundamentally important in understanding the structure, function, and evolutionary dynamics of biological systems. Gene duplication is a major mechanism of evolution for genetic novelties. Here, we demonstrate that genes evolved significantly more epistatic interactions after duplication. The connectivity of duplicate gene pairs in epistatic networks is pos...
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A population of complete subgraphs or cliques in a protein network model is studied. The network evolves via duplication and divergence supplemented with linking a certain fraction of target-replica vertex pairs. We derive a clique population distribution, which scales linearly with the size of the network and is in a perfect agreement with numerical simulations. Fixing both parameters of the m...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2004
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng1340